Introduction

Nephrotic syndrome is a disorder characterized by severe proteinuria,  hypoproteinemia,  and  generalized  edema resulting from damage to the glomerular basement mem- brane. In Western countries, nephrotic syndrome affects 2 of 100,000 children per year [1]. In Japan, approximately 1,300 new cases per year of pediatric nephrotic syndrome are reported to the Medical Aid for Specific Chronic Disease of Children and the disease develops in 5 of 100,000 children per year. Approximately 90%of the cases of pediatric

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